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Novel Antibodies for the Characterization of CAR-T Cells (31:47)

Learn how CAR linker antibodies can interrogate the expression of an... entire panel of CARs, fastser and easier than ever.

Analytical Tools to Evaluate CAR T-Cell Signaling & Activation (45:23)

Generation and Validation of Anti-Linker Monoclonal Antibodies for the Surface Detection of scFv-based CARs (5:25)

Download Research Posters

A novel monoclonal antibody for the detection, enrichment and activation of cells expressing scFv-based chimeric antigen receptors

In this poster, we report on a novel and highly versatile recombinant rabbit monoclonal antibody raised against the Gly₄Ser peptide linker, which is commonly integrated into single-chain variable fragment (scFv)-based CARs. This antibody can be leveraged for flow cytometry-based CAR detection, magnetic bead-based CAR-T cell enrichment, and selective activation of CAR transduced cells.

Generation and validation of anti-linker monoclonal antibodies for the surface detection of scFv-based CARs

AACRの年次総会で発表したこのポスターでは、CAR-T療法用に開発した、単鎖可変領域フラグメント (scFv) ベースのキメラ抗原受容体 (CAR) に一般的に用いられる2つのリンカー配列を認識する、ラビットモノクローナル抗体の作製と検証の詳細を紹介しています。